氟尼缩松是一种化学物质，分子式是C24H31FO6。

氟尼缩松 Flunisolide

中文别名：中国医学健康网氟尼缩松

英文别名：NasalideSyntaris

药品类别：肾上腺皮质激素类药

性状：本品适用于防治过敏性鼻炎，通过鼻孔给药极少引起全身不良反应。成人每鼻孔50μg/次，2-3次/d；维持量为每鼻孔25μg/d。5岁以上儿童每鼻子25μg/次，2次/d。

CAS：3385-03-3

分子式：C24H31FO6

分子量：434.5

药理药动

Classification:Corticosteroid

Action/Kinetics:Minimalsystemiceffectswithintranasaluse.Significantfirst-passafterinhalation;rapidlymetabolizedbytheliver.Severaldaysmayberequiredforfullbeneficialeffects.t1/2:1.8hr.Excretedbythefeces(40%)andurine(50%).

适应症

Inhalation:Prophylaxisofbronchialasthmaincombinationwithothertherapy.Forasthmaclientsrequiringsystemicsteroidswhereaddinganinhaledsteroidmaydecreaseoreliminatetheneedforsysltemicsteroids.Intranasal:Seasonalorperennialrhinitis,especiallyifothertreatmenthasprovenunsatisfactory.

用法用量

InhalationBronchialasthma.Adults:2inhalations(totalof500mcgflunisolide)ina.m.andp.m.,nottoexceed4inhalationsb.i.d.(i.e.,totaldailydoseof2,000mcg).Pediatric,6-15years:2inhalationsinthemorningandevening,withtotaldailydosenottoexceed1,000mcg.IntranasalRhinitis.Adults,initial:50mcg(2sprays)ineachnostrilb.i.d.;maybeincreasedto2sprayst.i.d.,uptomaximumdailydoseof400mcg(i.e.,8spraysineachnostril).Pediatric,6-14years,initial:25mcg(1spray)ineachnostrilt.i.d.or50mcg(2sprays)ineachnostrilb.i.d.,uptomaximumdailydoseof200mcg(i.e.,4spraysineachnostril).Maintenance,adults,children:Smallestdosenecessarytocontrolsymptoms.Someclients(approximately15%)arecontrolledon1sprayineachnostrildaily.

不良反应

Respiratory:Hoarseness,coughing,throatirritation;Candidainfectionsofnose,larynx,andpharynx.Afterintranasaluse:Nasopharyngealirritation,stinging,burning,dryness,headache.GI:Drymouth.Systemiccorticosteroideffects,especiallyifrecommendeddoseisexceeded.

注意事项

PregnancyCategory:C

Contraindications:ActiveorquiescentTB,especiallyoftherespiratorytract.Untreatedfungal,bacterial,systemicviralinfections.Ocularherpessimplex.Useuntilhealingoccursfollowingrecentulcerationofnasalseptum,nasalsurgery,ortrauma.Lactation.

SpecialConcerns:Safetyandeffectivenessinchildrenlessthan6yearsofagehavenotbeendetermined.